What is Globulin?

Most of that share is antibodies, which the immune system makes to recognise what the body has met before. The rest carries hormones, metals and other substances through the blood. A change in Globulin therefore means one of two things: the immune system has been more active, or the liver is making fewer carrier proteins.

Total Protein and Albumin are the two measured figures Globulin comes from: it is what is left when Albumin is taken off the total. A change in either of those measured figures therefore moves Globulin, whether or not the globulins themselves have changed.

Long-running infection or inflammation increases antibody production. The carrier proteins come from the liver, so liver disease reduces that part of it.

Antibody production shifts across weeks and months in response to sustained immune activity, and the liver's carrier proteins change on a similar scale, so Globulin drifts rather than jumps. A single reading is one point on that drift, and the year between measurements shows whether the drift has continued. This is Do Health's monitoring schedule, not a general recommendation for everyone.